16 May 1861 (+) is born in Gilmantown, United States.

4 July 1878 (x) marries Clara A. Lovering in Alton, United States.

28 January 1887 (x) marries Myrta Z. Belknap while he was still married to Clara Lovering in Minneapolis, United States.

25 December 1891 (-) murdered Julia Connor in Chicago, United States.

7 December 1892 (-) suffocated Emeline Cigrand in Chicago, United States.

5 July 1893 (-) murdered Minnie Williams in Chicago, United States.

9 January 1894 (x) marries Georgiana Yoke posing as Henry Mansfield Howard in Denver, United States.

4 September 1894 (-) murdered Benjamin Pitezel in Philadelphia, United States.

10 October 1894 (-) strangled Howard Pitezel in Indianapolis, United States.

25 October 1894 (x) 13-year-old Alice Etta and 10-year-old Nellie Rosa Pitezel are gassed and stuffed in a trunk by Holmes in Toronto, Canada.

28 October 1895 (x) Start of the trial against Holmes for the murder of the Pitezel children in the Court of Oyer and Terminer in Philadelphia, United States.

7 May 1896 (-) is executed by hanging in Philadelphia, United States.